Prevalence, incidence, and medications of narcolepsy in Japan: a descriptive observational study using a health insurance claims database

Abstract The objectives of this study were to describe prevalence, incidence, and medications among patients who diagnosed with narcolepsy in Japan using a claims database. Patients identified from January 2010 December 2019 an employment-based health insurance database compiled by JMDC Inc. prevalence incidence estimated annually the overall population age sex employees their dependents aged < 75 years. Medications, examined for each quarter population, modafinil, methylphenidate, pemoline, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine inhibitors. We 1539 narcolepsy. annual increased 5.7 18.5/100,000 persons 2019, respectively. Large increases found 20–29 years 10–19 years, highest (9.7–37.5/100,000 5.0–27.1/100,000 persons). slightly 3.6 4.3/100,000 person-year was (5.8–11.3/100,000 person-year, 3.8–7.4/100,000 respectively). Methylphenidate modafinil commonly prescribed (27.3–38.9% 17.5–45.5%, prescriptions declined during 10 whereas (15.6–17.1% 43.8–45.8% appeared increase especially teenagers 20-year olds.